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CAY10789

CAT: 0804-HY-147086-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147086-01Size:1 mg
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Description
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM) . CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].
CAS Number
[123226-28-8]
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1; Leukotriene Receptor; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cay10789.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCC1=CC=CC(OCC2=NC3=CC=CC=C3C=C2)=C1
Molecular Formula
C17H15NO2
Molecular Weight
265.31
References & Citations
[1]Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64 (22) :16512-16529.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTD4/CysLT1; TNFRSF5/CD40

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