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CAY10669

CAT: 0804-HY-117617-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117617-01Size:1 mg
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Description
CAY10669 (compound 6d) is an anacardic acid derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM[1]. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells[1][2][3].
CAS Number
1243583-88-1
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cay10669.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
OC1=CC=CC(/C=C\C2=CC=C(C=C2)OCCCCC)=C1C(O)=O
Molecular Formula
C20H22O4
Molecular Weight
326.39
References & Citations
[1]Ghizzoni M, et al., Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorg Med Chem. 2010 Aug 15;18 (16) :5826-34.|[2]Farr GH 3rd, et al., A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2020 Oct 15;10 (1) :29.|[3]Christensen MD, et al., An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA. J Control Release. 2018 Sep 28;286:210-223.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GCN5/PCAF

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