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PD 121373

CAT: 0804-HY-124116Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124116Size:1 Each
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Description
PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the synthesis of DNA and RNA. The IC50 values of PD 121373 for inhibiting DNA and RNA synthesis in L1210 cells are 0.5 μM and 0.3 μM, respectively[1].
CAS Number
113457-06-0
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-121373.html
Smiles
OC1=CC2=C(SC3=C(NCCN)C=CC4=C3C2=NN4CCN(CC)CC)C=C1
Molecular Formula
C21H27N5OS
Molecular Weight
397.54
References & Citations
[1]DAVID W, et al. "Biochemical pharmacology and DNA-drug interactions by Cl-958, a new antitumor intercalator derived from a series of substituted 2H-[1] benzothiopyrano [4, 3, 2-cd] indazoles." Molecular pharmacology 33.1 (1988) : 84-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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