TGP-377/421

CAT: 0804-HY-138647-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-138647-02Size:10 mM - 1 mL

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Description

TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs[1].

CAS Number

16752-89-9

Product Name Alternative

Targapre-miR-377/421

UNSPSC

12352005

Target

MicroRNA

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tgp-377-421.html

Purity

98.17

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

NC1=CC=C2C(N=C(C3=CC=CC(C4=NC5=CC(N)=CC=C5N4)=C3)N2)=C1

Molecular Formula

C20H16N6

Molecular Weight

340.38

References & Citations

[1]Haniff HS, et al. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12 (10) :952-961.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

2,2'-(1,3-Phenylene)bis(1H-benzo[d]imidazol-6-amine)

CAS Number	16752-89-9
PubChem CID	708725
IUPAC Name	2-[3-(6-amino-1H-benzimidazol-2-yl)phenyl]-3H-benzimidazol-5-amine
Molecular Formula	C20H16N6
Molecular Weight	340.4
XLogP	3
Topological Polar Surface Area	109
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	26
Formal Charge	0
Complexity	459

SMILES

C1=CC(=CC(=C1)C2=NC3=C(N2)C=C(C=C3)N)C4=NC5=C(N4)C=C(C=C5)N

InChI

InChI=1S/C20H16N6/c21-13-4-6-15-17(9-13)25-19(23-15)11-2-1-3-12(8-11)20-24-16-7-5-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)

InChIKey

AQEJANNNADGRSY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 16752-89-9

CID: 708725

Formula: C20H16N6

MW: 340.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	340.4
XLogP3	3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	340.14364454
Monoisotopic Mass	340.14364454
Topological Polar Surface Area	109 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	459
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-176805	TGP-377
HY-110117-01	BIRT 377
HY-120155	MS-377
HY-114215-01	DSM-421
HY-W952980	CRBN ligand-377
HY-114958	RH 421
HY-P5121	γ-Fibrinogen 377-395
HY-P5121A-01	γ-Fibrinogen 377-395 (TFA)
HY-142547S-01	S 421-d4
HY-W953410	CRBN ligand-421

Alternative Products

Catalog	Name
BUP08451-01	TGP-377/421
T212401-01	TGP-377
GTR19260179-01	TGP-29b-066
9520-25	AHU-377
MBS3842177-01	BIRT-377
MBS3603214	MS-377
4776/10	BIRT 377
sc-492600	AHU 377

TGP-377/421

Chemical Information

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