TGP-377

• Description :

  TGP-377 is a potent miR-377 inhibitor that specifically and effectively enhances VEGFA expression by targeting the non-coding microRNA that regulates VEGFA expression[1].

• UNSPSC :

  12352100

• Target :

  MicroRNA; VEGFR

• Related Pathways :

  Epigenetics; Protein Tyrosine Kinase/RTK

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C(CN(CCCN1N=NC(CN2CCN(CC2)C3=CC(NC4=NC=CC(NC5=CC=C6C=CC=CC6=N5)=C4)=NC(C)=N3)=C1)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CCCOC7=CC(C8=NC9=CC=C(C=C9N8)N)=CC(C%10=NC%11=C(N%10)C=C(N)C=C%11)=C7)=O)=O)=O)=O)=O)N

• Molecular Formula :

  C75H93N23O7

• Molecular Weight :

  1428.69

• References & Citations :

  [1]Haniff HS, et al. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12 (10) :952-961.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2665700-67-2]