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BIRT 377

CAT: 0804-HY-110117-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110117-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) . BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].
CAS Number
213211-10-0
UNSPSC
12352005
Target
Integrin; Interleukin Related
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/birt-377.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O
Molecular Formula
C18H15BrCl2N2O2
Molecular Weight
442.13
References & Citations
[1]Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163 (10) :5173-5177.|[2]Lanzloth R, et al. Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition[J]. bioRxiv, 2025: 2025.03. 19.644113.|[3]Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429 (1-3) :297-302.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2

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