BIRT 377

• Description:

  BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) . BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

• UNSPSC:

  12352005

• Target:

  Integrin; Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/birt-377.html

• Purity:

  99.82

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1N (C2=CC (Cl) =CC (Cl) =C2) C (N (C) [C@]1 (C) CC3=CC=C (Br) C=C3) =O

• Molecular Formula:

  C18H15BrCl2N2O2

• Molecular Weight:

  442.13

• References & Citations:

  [1]Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163 (10) :5173-5177.|[2]Lanzloth R, et al. Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition[J]. bioRxiv, 2025: 2025.03. 19.644113.|[3]Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429 (1-3) :297-302.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IL-2

• CAS Number:

  213211-10-0