BIRT 377

• UNSPSC Description:

  BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

• Target Antigen:

  Integrin; Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton;Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/birt-377.html

• Purity:

  98.07

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O

• Molecular Weight:

  442.13

• References & Citations:

  [1]Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  213211-10-0