MS-377

• Description :

  MS-377 is a selective and orally active sigma-1 receptor ligand (Ki=73 nM) with weak affinity for sigma-2 receptor (Ki=6900 nM) and no affinity for any other receptors including dopamine, serotonin, PCP site, glutamate, γ-aminobutylic acid, adenosine, adrenergic receptors, etc. (Ki: >10 μM) . MS-377 indirectly modulates the NMDA receptor ion-channel complex. MS-377 is a antipsychotic agent. MS-377 inhibits PCP-induced behaviors by inhibition of the increase in dopamine and serotonin release in the rat medial prefrontal cortex. MS-377 can be used for research of schizophrenia[1][2].

• CAS Number :

  [206862-30-8]

• UNSPSC :

  12352005

• Target :

  IGluR; Sigma Receptor

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  O=C1N(C2=CC=C(Cl)C=C2)CC[C@@H]1CN3CCN(CCOC)CC3

• Molecular Formula :

  C18H26ClN3O2

• Molecular Weight :

  351.87

• References & Citations :

  [1]Karasawa, et al. MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells. Life Sci. 2002 Feb 22;70 (14) :1631-42. |[2]Takahashi S, et al. MS-377, a novel selective sigma (1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain. Eur J Pharmacol. 2001 Sep 21;427 (3) :211-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Sigma 1 Receptor; Sigma 2 Receptor