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BI 665915

CAT: 0804-HY-12995Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12995Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI 665915, a chemical probe, is an orally active and potent 5-lipoxygenase-activating protein (FLAP) inhibitor. BI 665915 inhibits FLAP production that blocks LTB4 biosynthesis in mice. BI 665915 is promising for research of various inflammatory diseases, including respiratory and cardiovascular diseases[1].
CAS Number
1360550-04-4
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bi-665915.html
Smiles
C[C@@](C1CC1)(C2=CC=C(C3=CN=C(N)N=C3)C=C2)C4=NOC(C5=CN(N=C5)CC(N(C)C)=O)=N4
Molecular Formula
C24H26N8O2
Molecular Weight
458.52
References & Citations
[1]Takahashi H, et al. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4- (3-{ (R) -1-[4- (2-amino-pyrimidin-5-yl) -phenyl]-1-cyclopropyl-ethyl}-[1, 2, 4] oxadiazol-5-yl) -pyrazol-1-yl]-N, N-dimethyl-acetamide (BI 665915) [J]. Journal of Medicinal Chemistry, 2015, 58 (4) : 1669-1690.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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