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Dimethyl itaconate

CAT: 0804-HY-W041892-01Size: 100 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W041892-01Size:100 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dimethyl itaconate induces innate immune memory (trained immunity), and exhibits immunomodulatory property. Dimethyl itaconate inhibits the activation of microglia, reduces the neuroinflammation and synaptic structural damage. Dimethyl itaconate regulates the composition of intestinal flora[1][2].
CAS Number
617-52-7
UNSPSC
12352200
Hazard Statement
H315, H334, H401
Target
Reactive Oxygen Species (ROS)
Type
Biochemical Assay Reagents
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dimethyl-itaconate.html
Purity
99.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C(C(C(OC)=O)=C)C(OC)=O
Molecular Formula
C7H10O4
Molecular Weight
158.15
Precautions
H315, H334, H401
References & Citations
[1]Ferreira AV, et al., Dimethyl itaconate induces long-term innate immune responses and confers protection against infection. Cell Rep. 2023 Jun 27;42 (6) :112658.|[2]Pan W, et al., Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice. Microbiome. 2023 Feb 21;11 (1) :30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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