4-Octyl itaconate

• Description :

  4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1[1].

• Product Name Alternative :

  4-OI

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/4-octyl-itaconate.html

• Purity :

  99.92

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OCCCCCCCC)CC(C(O)=O)=C

• Molecular Formula :

  C13H22O4

• Molecular Weight :

  242.31

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556 (7699) :113-117.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3133-16-2]