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Itaconate-alkyne

CAT: 0804-HY-133870-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133870-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2454181-83-8
Product Name Alternative
ITalk
UNSPSC
12352211
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/itaconate-alkyne.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C(CC(OCCCCCCC#C)=O)=C
Molecular Formula
C13H18O4
Molecular Weight
238.28
References & Citations
[1]Wei Qin, et al. Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages. J Am Chem Soc . 2020 Jun 24;142 (25) :10894-10898.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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