REDV (TFA)

• Description:

  REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV TFA can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1 (α4β1) . REDV TFA can be used for the research of cell adhesion[1].

• UNSPSC:

  12352209

• Target:

  Integrin

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/redv-tfa.html

• Purity:

  99.81

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)[C@H](CCCNC(N)=N)N.O=C(O)C(F)(F)F.[x]

• Molecular Formula:

  C20H35N7O9.xC2HF3O2

• Molecular Weight:

  517.53 (free acid)

• References & Citations:

  [1]S P Massia, et al. Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J Biol Chem. 1992 Jul 15;267 (20) :14019-26.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported