Tauroursodeoxycholate-d4-1

• Description:

  Tauroursodeoxycholate-d4-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

• Product Name Alternative:

  Tauroursodeoxycholic acid-d4-1; TUDCA-d4-1; UR 906-d4-1

• UNSPSC:

  12352211

• Target:

  Apoptosis; Caspase; Endogenous Metabolite; ERK; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@] (CC[C@]2 ([H]) [C@H] (C) CCC (NC ([2H]) ([2H]) C ([2H]) ([2H]) S (=O) (O) =O) =O) ([H]) [C@@]3 ([H]) [C@@] (CC1) ([H]) [C@@]4 ([C@] (C[C@@H] (CC4) O) ([H]) C[C@@H]3O) C

• Molecular Formula:

  C26H41D4NO6S

• Molecular Weight:

  503.73

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92 (2) :307-16.|[3]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53 (3) :337-345.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2573035-17-1