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Tauroursodeoxycholate-d4

CAT: 0804-HY-19696S1Size: 100 μg (198.52 μM x 1 mL in Methanol)Dry Ice: NoHazardous: No
CAT#:0804-HY-19696S1Size:100 μg (198.52 μM x 1 mL in Methanol)
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Description
Tauroursodeoxycholate-d4 is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
CAS Number
[2410279-94-4]
Product Name Alternative
Tauroursodeoxycholic acid-d4; TUDCA-d4; UR 906-d4
UNSPSC
12352211
Hazard Statement
H225, H370
Target
Apoptosis; Caspase; Endogenous Metabolite; ERK; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Concentration
198.52 μM * 1 mL in Methanol
Purity
99.7
Solubility
10 mM in DMSO
Smiles
O=S(CCNC(CC[C@H]([C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@]12C)C)=O)(O)=O
Molecular Formula
C26H41D4NO6S
Molecular Weight
503.73
Precautions
H225, H370
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92 (2) :307-16.|[3]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53 (3) :337-345.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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