Tauroursodeoxycholate (dihydrate) (Standard)

• Description:

  Tauroursodeoxycholate (dihydrate) (Standard) is the analytical standard of Tauroursodeoxycholate (dihydrate) . This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].

• Product Name Alternative:

  Tauroursodeoxycholic acid (dihydrate) (Standard) ; TUDCA (dihydrate) (Standard) ; UR 906 (dihydrate) (Standard)

• UNSPSC:

  12352100

• Target:

  Apoptosis; Caspase; Endogenous Metabolite; ERK; Reference Standards

• Related Pathways:

  Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  C[C@H] (CCC (NCCS (=O) (O) =O) =O) [C@H]1CC[C@@]2 ([H]) [C@]3 ([H]) [C@@H] (O) C[C@]4 ([H]) C[C@H] (O) CC[C@]4 (C) [C@@]3 ([H]) CC[C@]12C.O.O

• Molecular Formula:

  C26H49NO8S

• Molecular Weight:

  535.73

• References & Citations:

  [1]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92 (2) :307-16.|[2]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53 (3) :337-345.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• Clinical Information:

  Launched

• CAS Number:

  117609-50-4