Dynole 34-2

• Description:

  Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) [1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Apoptosis; Dynamin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dynole-34-2.html

• Concentration:

  10mM

• Purity:

  99.25

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  N#C/C(C(NCCCCCCCC)=O)=C\C1=CN(CCCN(C)C)C2=C1C=CC=C2

• Molecular Formula:

  C25H36N4O

• Molecular Weight:

  408.58

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10 (9) :1553-62. |[2]Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52 (12) :3762-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1128165-88-7]