Dynole 34-2

CAT: 0804-HY-107545-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107545-01Size:1 mg
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Description
Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) [1][2].
CAS Number
[1128165-88-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Dynamin
Type
Reference compound
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dynole-34-2.html
Concentration
10mM
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C(NCCCCCCCC)=O)=C\C1=CN(CCCN(C)C)C2=C1C=CC=C2
Molecular Formula
C25H36N4O
Molecular Weight
408.58
Precautions
H302, H315, H319
References & Citations
[1]Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10 (9) :1553-62. |[2]Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52 (12) :3762-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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