SARS-CoV-2 Mpro-IN-34

SARS-CoV-2 Mpro-IN-34

• UNSPSC Description: SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for SARS-CoV-2 Mpro with an IC50 of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC50 of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC50 of 0.103 μM[1].
• Target Antigen: SARS-CoV; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-mpro-in-34.html
• Smiles: O=C([C@@H](CC1=C(Cl)C=C(Cl)C=C1)N(C(C[C@@H]2N3CC4(CC4)C2)=O)C)NCCCCCCNC5=CC(C3=O)=CN=C5
• Molecular Weight: 586.55
• References & Citations: [1]Wang X, et al., Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants. J Med Chem. 2024 Nov 14;67(21):19623-19667.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported