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Dynole 2−24

CAT: 0804-HY-145080-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145080-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I) . Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀ (CME) =1.9 μM) . Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis
CAS Number
1416313-72-8
UNSPSC
12352005
Target
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dynole-2-24.html
Purity
99.07
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2
Molecular Formula
C24H41N3
Molecular Weight
371.60
References & Citations
[1]Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56 (1) :46-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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