Dynole 2−24

• Description :

  Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I) . Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀ (CME) =1.9 μM) . Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

• UNSPSC :

  12352005

• Target :

  Dynamin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dynole-2-24.html

• Purity :

  99.07

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  CN(C)CCCN1C=C(CNCCCCCCCCCC)C2=C1C=CC=C2

• Molecular Formula :

  C24H41N3

• Molecular Weight :

  371.60

• References & Citations :

  [1]Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56 (1) :46-59.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1416313-72-8]