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CX516-d10

CAT: 0804-HY-10933S-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10933S-02Size:10 mg
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Description
CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) [1].
CAS Number
1286653-21-1
Product Name Alternative
BDP 12-d10
UNSPSC
12352005
Target
IGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(N1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H])C2=CC3=C(N=CC=N3)C=C2
Molecular Formula
C14H5D10N3O
Molecular Weight
251.35
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl) . 2009 Nov;206 (4) :631-40.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Chemical Information

Ampalex-d10
CAS Number1286653-21-1
PubChem CID71313390
IUPAC Name(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)-quinoxalin-6-ylmethanone
Molecular FormulaC14H15N3O
Molecular Weight251.35
XLogP1.8
Topological Polar Surface Area46.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity301
SMILES
[2H]C1(C(C(N(C(C1([2H])[2H])([2H])[2H])C(=O)C2=CC3=NC=CN=C3C=C2)([2H])[2H])([2H])[2H])[2H]
InChI
InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2/i1D2,2D2,3D2,8D2,9D2
InChIKey
ANDGGVOPIJEHOF-YRRFPNITSA-N
Chemical Structure
2D Structure
2D structure of Ampalex-d10
CAS: 1286653-21-1
CID: 71313390
Formula: C14H15N3O
MW: 251.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight251.35
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass251.184279570
Monoisotopic Mass251.184279570
Topological Polar Surface Area46.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity301
Isotope Atom Count10
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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