PF-05085727

• Description :

  PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM) . PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/PF-05085727.html

• Concentration :

  10mM

• Purity :

  99.53

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  CN1C2=NC=NC(N3CCC3)=C2C(C4=C(C5=CC=C(C(F)(F)F)C=C5)N(C)N=C4)=N1

• Molecular Formula :

  C20H18F3N7

• Molecular Weight :

  413.40

• References & Citations :

  [1]Helal CJ, et al. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J Med Chem. 2017 Jul 13;60 (13) :5673-5698.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE2

• CAS Number :

  [1415637-72-7]