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SB-328437

CAT: 0804-HY-103363-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103363-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU -resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases[1][2][3].
CAS Number
247580-43-4
UNSPSC
12352005
Hazard Statement
H302, H400
Target
CCR; Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-328437.html
Purity
99.58
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(OC)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=C3C=CC=CC3=CC=C2)=O
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
Precautions
H302, H400
References & Citations
[1]White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275 (47) :36626-31. |[2]Gutiérrez Á, et al. Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights. Oncol Lett. 2024 May 1;28 (1) :296.|[3]Lopez-Leal F, et al. Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation. J Leukoc Biol. 2024 Nov 4;116 (5) :1198-1207.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR3

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