SB-328437

• Description :

  SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU (HY-90006) -resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H400

• Target :

  CCR; Thymidylate Synthase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sb-328437.html

• Purity :

  99.58

• Solubility :

  DMSO : 87.5 mg/mL (ultrasonic)

• Smiles :

  O=C(OC)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=C3C=CC=CC3=CC=C2)=O

• Molecular Formula :

  C21H18N2O5

• Molecular Weight :

  378.38

• Precautions :

  H302, H400

• References & Citations :

  [1]White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275 (47) :36626-31. |[2]Gutiérrez Á, et al. Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights. Oncol Lett. 2024 May 1;28 (1) :296.|[3]Lopez-Leal F, et al. Blockade of the CCR3 receptor reduces neutrophil recruitment to the lung during acute inflammation. J Leukoc Biol. 2024 Nov 4;116 (5) :1198-1207.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CCR3

• CAS Number :

  [247580-43-4]