SB-649868

CAT: 0804-HY-10806-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10806-01Size:5 mg
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Description
SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively) .
CAS Number
[380899-24-1]
Product Name Alternative
GSK649868
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SB-649868.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(F)C=C2)SC(C)=N1)N3CCCC[C@H]3CNC(C4=C(C=CO5)C5=CC=C4)=O
Molecular Formula
C26H24FN3O3S
Molecular Weight
477.55
Precautions
H315, H319, H335
References & Citations
[1]Di Fabio R, et al. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2receptor antagonist useful for treatment of sleep disorders. Bioorg Med Chem Lett. 2011 Sep 15;21 (18) :5562-7.|[2]Faedo S, et al. Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptorantagonists. Eur J Pharmacol. 2012 Oct 5;692 (1-3) :1-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
OX2 Receptor

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Alternative Products

CatalogName
MBS5764895SB-649868
A12651-1SB-649868 1mg
A12651-50SB-649868 50mg
A12651-5SB-649868 5mg
A12651-10SB-649868 10mg
A12651-25SB-649868 25mg
A12651-100SB-649868 100mg
A12651-200SB-649868 200mg
A12651-10mM-DSB-649868 10mM * 1mL in DMSO
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