SB 414240

CAT: 0804-HY-122286Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-122286Size:1 Each
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Description
SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist with Kis of 1 nM and 193 nM for human NK-3R and human NK-2R, respectively. SB 414240 does not bind the human μ-opioid receptor (hMOR) . SB 414240 can be used for the study of neurological disease[1].
CAS Number
[272104-60-6]
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N[C@@H](C)C(C)(C)C)C1=C(C(C2=CC=CC=C2)=NC3=CC=CC=C13)CN4CCC(CC4)N5CCCCC5
Molecular Formula
C33H44N4O
Molecular Weight
512.73
References & Citations
[1]Blaney FE, et al. Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. J Med Chem. 2001 May 24;44 (11) :1675-89.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK2R; NK3R

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