SB 414240

• Description:

  SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist with Kis of 1 nM and 193 nM for human NK-3R and human NK-2R, respectively. SB 414240 does not bind the human μ-opioid receptor (hMOR) . SB 414240 can be used for the study of neurological disease[1].

• UNSPSC:

  12352005

• Target:

  Neurokinin Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=C (N[C@@H] (C) C (C) (C) C) C1=C (C (C2=CC=CC=C2) =NC3=CC=CC=C13) CN4CCC (CC4) N5CCCCC5

• Molecular Formula:

  C33H44N4O

• Molecular Weight:

  512.73

• References & Citations:

  [1]Blaney FE, et al. Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. J Med Chem. 2001 May 24;44 (11) :1675-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NK2R; NK3R

• CAS Number:

  272104-60-6