Galanthamine (hydrobromide) (Standard)

CAT: 0804-HY-A0009R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0009R-01Size:5 mg
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Description
Galanthamine (hydrobromide) (Standard) is the analytical standard of Galanthamine (hydrobromide) . This product is intended for research and analytical applications. Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors (nAChRs) . Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) [1][2][3].
CAS Number
[1953-04-4]
Product Name Alternative
Galantamine (hydrobromide) (Standard)
UNSPSC
12352005
Target
Cholinesterase (ChE) ; nAChR; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/galanthamine-hydrobromide-standard.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC.Br
Molecular Formula
C17H22BrNO3
Molecular Weight
368.27
References & Citations
[1]L J Scott, et al. Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60 (5) :1095-122.|[2]Marek Samochocki, et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. Pharmacol Exp Ther. 2003 Jun;305 (3) :1024-36.|[3]Acharya Balkrishna, et al. Anti-Acetylcholinesterase Activities of Mono-Herbal Extracts and Exhibited Synergistic Effects of the Phytoconstituents: A Biochemical and Computational Study. Molecules. 2019 Nov; 24 (22) : 4175.|[4]Balpreet Matharu, et al. Galantamine inhibits beta-amyloid aggregation and cytotoxicity. J Neurol Sci. 2009 May 15;280 (1-2) :49-58.|[5]Debby Van Dam, et al. Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berl) . 2005 Jun;180 (1) :177-90.|[6]Johan Monbaliu, et al. Pharmacokinetics of galantamine, a cholinesterase inhibitor, in several animal species. Arzneimittelforschung. 2003;53 (7) :486-95.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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