Galanthamine

• UNSPSC Description:

  Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

• Target Antigen:

  Apoptosis; Cholinesterase (ChE)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Galanthamine.html

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 59 mg/mL

• Smiles:

  O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC

• Molecular Weight:

  287.359

• References & Citations:

  [1]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.|[2]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43.|[3]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51.Antioxidants (Basel). 2022 Feb 14;11(2):385.|Asian Pac J Trop Med. 2018, 8(10):500-512.|Biochem Pharmacol. 2020 Oct;180:114139.|bioRxiv. 2023 Jun 3.|J Chromatogr A. 2023 Aug 25, 464330.|J Pharmacol Sci. 21 February 2022.|Microorganisms. 2022, 10(10), 2089.|Nat Commun. 2023 Apr 17;14(1):2182.|PLoS Biol. 2024 June 27.|Research Square Preprint. June 16th, 2022.|Acta Pharmacol Sin. 2024 Mar 4.|Antioxidants (Basel). 2022, 11(7), 1228.|Free Radic Biol Med. 2019 Dec;145:20-32.|Heliyon. 2024 Jun 03.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  357-70-0