Galanthamine

• Description :

  Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

• Product Name Alternative :

  Galantamine

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H317, H331

• Target :

  Apoptosis; Cholinesterase (ChE)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Galanthamine.html

• Purity :

  99.90

• Solubility :

  DMSO : ≥ 59 mg/mL

• Smiles :

  O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC

• Molecular Formula :

  C17H21NO3

• Molecular Weight :

  287.36

• Precautions :

  H301, H315, H317, H331

• References & Citations :

  [1]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (SI 1) :67-86.|[2]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2 (*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74 (1) :132-43.|[3]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl) . 2013 Feb;225 (3) :543-51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  AChE

• Citation 01 :

  Antioxidants (Basel) . 2022 Feb 14;11 (2) :385.|Asian Pac J Trop Med. 2018, 8 (10) :500-512.|Biochem Pharmacol. 2020 Oct;180:114139.|bioRxiv. 2024 Apr 3:2023.06.02.542933.|bioRxiv. 2025 Sep 21.|J Chromatogr A. 2023 Oct 11:1708:464330.|J Pharmacol Sci. 2022 Apr;148 (4) :364-368.|Microorganisms. 2022 Oct 21;10 (10) :2089.|Nat Commun. 2023 Apr 17;14 (1) :2182.|PLoS Biol. 2024 Jun 27;22 (6) :e3002672.|Research Square Preprint. June 16th, 2022.|Acta Pharmacol Sin. 2024 Jun;45 (6) :1160-1174.|Antioxidants (Basel) . 2022 Jun 23;11 (7) :1228.|Free Radic Biol Med. 2019 Dec;145:20-32.|Heliyon. 2024 Jun 3;10 (11) :e32322.

• CAS Number :

  [357-70-0]