CC-401

CAT: 804-HY-13022A-01Size: 1 mgDry Ice: NoHazardous: No

1 mgSelected

PRICE

AVAILABILITY

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.

CAS Number

[395104-30-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cc-401.html

Purity

99.63

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5

Molecular Formula

C22H24N6O

Molecular Weight

388.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18 (2) :472-84.|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21 (18) :4143-52.|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89 (4) :470-84.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

JNK

Citation 01

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Catalog	Name
MBS384461-01	CC-401
444046-01	CC-401
MBS3604358-01	CC-401
B1260-5	CC-401
B1260-50	CC-401
MBS5757124	CC-401
sc-364748A	CC-401
M14359-01	CC-401
BISN0256-01	Cc-401
B1260-5.1	CC-401

CC-401

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