CC-401

• UNSPSC Description:

  CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.

• Target Antigen:

  JNK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cc-401.html

• Purity:

  98.60

• Solubility:

  DMSO : 39.7 mg/mL (ultrasonic;warming)

• Smiles:

  C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5

• Molecular Weight:

  388.47

• References & Citations:

  [1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84.Cell Syst. 2018 Apr 25;6(4):424-443.e7.|J Med Chem. 2023 Mar 6.|Mol Cancer Res. 2016 Aug;14(8):753-63.|Harvard Medical School LINCS LIBRARY|Science. 2017 Dec 1;358(6367):eaan4368.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Phase 2

• CAS Number:

  395104-30-0