CC-401

CAT: 0804-HY-13022A-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-13022A-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.

CAS Number

395104-30-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cc-401.html

Purity

99.63

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5

Molecular Formula

C22H24N6O

Molecular Weight

388.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18 (2) :472-84.|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21 (18) :4143-52.|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89 (4) :470-84.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

JNK

Citation 01

Chemical Information

Cc-401

3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole is a member of pyrazoles and a ring assembly.

CAS Number	395104-30-0
PubChem CID	10430360
IUPAC Name	3-[3-(2-piperidin-1-ylethoxy)phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
Molecular Formula	C22H24N6O
Molecular Weight	388.5
XLogP	3.8
Topological Polar Surface Area	82.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	29
Formal Charge	0
Complexity	516

SMILES

C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5

InChI

InChI=1S/C22H24N6O/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27)

InChIKey

XDJCLCLBSGGNKS-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 395104-30-0

CID: 10430360

Formula: C22H24N6O

MW: 388.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	388.5
XLogP3	3.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	388.20115941
Monoisotopic Mass	388.20115941
Topological Polar Surface Area	82.7 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	516
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-P991542	GBR-401
HY-131181-01	LEI-401
HY-163737-01	ST-401
HY-19554	MM-401
HY-108238	BSI-401
HY-109804-01	CORM-401
HY-178230	EVT‑401
HY-12537-01	Peptide 401
HY-12312-01	TCS 401
HY-19341-01	Compound 401

Alternative Products

Catalog	Name
sc-364748	CC-401
MBS132131-01	CC 401
T36673-01	CC 401 dihydrochloride
MBS3601859-01	CC-401 hydrochloride
A11352-10	CC-401 10mg
574621	CC-401 HCl

CC-401

Chemical Information

Related Products

Alternative Products

Popular Products