Compound 401

• Description:

  Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  DNA-PK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Compound-401.html

• Purity:

  99.97

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C1C=C(N2CCOCC2)N=C3N1C=CC4=C3C=CC=C4

• Molecular Formula:

  C16H15N3O2

• Molecular Weight:

  281.31

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ballou LM, et al. Inhibition of mammalian target of rapamycin signaling by 2- (morpholin-1-yl) pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282 (33) :24463-70.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  168425-64-7