BSI-401

• Description:

  BSI-401 is an orally active PARP-1 inhibitor. BSI-401 alone and in synergism with Oxaliplatin (HY-17371) inhibits pancreatic cancer[1].

• UNSPSC:

  12352005

• Target:

  PARP

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C1C=CC2=C(I)C([N+]([O-])=O)=CC=C2O1

• Molecular Formula:

  C9H4INO4

• Molecular Weight:

  317.04

• References & Citations:

  [1]Melisi D, et al. Oral poly (ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. Clin Cancer Res. 2009 Oct 15;15 (20) :6367-77.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PARP1

• CAS Number:

  [142404-10-2]