CTCE-9908 (TFA)

CAT: 0804-HY-P1103ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1103ASize:1 Each
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Description
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells[1][2].
UNSPSC
12352209
Target
CXCR
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ctce-9908-tfa.html
Solubility
H2O
Smiles
OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@@H](CCCCNC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)=O)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)C=C1.O=C(C(F)(F)F)O
Molecular Formula
C88H148F3N27O25
Molecular Weight
2041.28
References & Citations
[1]Joseph Kwong, et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther. 2009 Jul;8 (7) :1893-905.|[2]Saima Hassan, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer. 2011 Jul 1;129 (1) :225-32.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
CXCR4

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