CTCE-9908 (TFA)

• Description:

  CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells[1][2].

• UNSPSC:

  12352209

• Target:

  CXCR

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ctce-9908-tfa.html

• Solubility:

  H2O

• Smiles:

  OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@@H](CCCCNC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)=O)CCCNC(N)=N)=O)C(N)=O)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCCCN)N)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)C=C1.O=C(C(F)(F)F)O

• Molecular Formula:

  C88H148F3N27O25

• Molecular Weight:

  2041.28

• References & Citations:

  [1]Joseph Kwong, et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther. 2009 Jul;8 (7) :1893-905.|[2]Saima Hassan, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer. 2011 Jul 1;129 (1) :225-32.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  CXCR4