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NITD-916

CAT: 0804-HY-122643-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122643-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects[1][2].
CAS Number
1614262-83-7
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nitd-916.html
Purity
99.83
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(C2=CC=CC=C2)=C(O)C=C(CC3CCC(C)(C)CC3)N1
Molecular Formula
C20H25NO2
Molecular Weight
311.42
References & Citations
[1]Ujjini H Manjunatha, et al. Direct inhibitors of InhA are active against Mycobacterium tuberculosis. Sci Transl Med. 2015 Jan 7;7 (269) :269ra3.|[2]Matthew B McNeil, et al. Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA. Tuberculosis (Edinb) . 2017 Dec;107:133-136.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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