VCH-916

CAT: 0804-HY-13465-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13465-01Size:5 mg
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Description
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor. IC50 Value: Target: HCV VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. VCH-916 is currently being evaluated for safety/tolerability, pharmacokinetics and anti-viral efficacy in chronically infected HCV patient.
CAS Number
[1200133-34-1]
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/VCH-916.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N([C@H]2CC[C@H](OC)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C4=CCCCC4)S1)O[K]
Molecular Formula
C26H36KNO4S
Molecular Weight
497.73
References & Citations
[1]Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver International. 2013,33 (s1) : 85-92|[2]Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry. 2012, 20 (10) : 3150-3161.|[3]Debasis Dasa, Jian Honga, Shu-Hui Chena, et al. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry. 2011, 19 (16) : 4690-4703|[4]Pierre L Beaulieu. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Informahealthcare. 2009, 19 (2) : 145-164|[5]Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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Alternative Products

CatalogName
MBS132565-01VCH-916
A12374-5VCH-916 5mg
A12374-10VCH-916 10mg
A12374-50VCH-916 50mg
A12374-100VCH-916 100mg
A12374-2VCH-916 2mg
A12374-25VCH-916 25mg
MF-0016002-01VCH-916 free acid (1200133-34-1 free base)
MBS3614563-01VCH-916 free acid(1200133-34-1 free base)
MBS3841133-01VCH-759

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