Alpha-Hederin

CAT: 0804-HY-N0255-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0255-01Size:5 mg
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Description
Alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway[1].
CAS Number
[27013-91-8]
Product Name Alternative
α-Hederin
UNSPSC
12352005
Hazard Statement
H413
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/alpha-Hederin.html
Purity
99.11
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
OC[C@@]1(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@@]5([H])C4=CC[C@]3([H])[C@@]2(C)CC[C@@H]1O[C@]6([H])OC[C@H](O)[C@H](O)[C@H]6O[C@@]7([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7
Molecular Formula
C41H66O12
Molecular Weight
750.96
Precautions
H413
References & Citations
[1]Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60 (1) :45-9.|[2]Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60 (1) :45-9.|[3]Wang J, et al. α-Hederin induces the apoptosis of gastric cancer cells accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway. Phytother Res. 2020;34 (3) :601-611.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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