β-Hederin

• Description :

  β-Hederin, a saponin isolated from Hedera helix L. (Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/β-hederin.html

• Purity :

  97.0

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CCC(C)(C4)C)C(O)=O)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)C)([H])CC2)C)C

• Molecular Formula :

  C41H66O11

• Molecular Weight :

  734.96

• References & Citations :

  [1]F Delmas, et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med. 2000 May;66 (4) :343-7.|[2]O Ridoux, et al. In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A (1), in association with pentamidine and amphotericin B. Phytother Res. 2001 Jun;15 (4) :298-301.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Leishmania

• CAS Number :

  [35790-95-5]