CDDO-dhTFEA

CAT: 0804-HY-112671-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112671-01Size:5 mg
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Description
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].
CAS Number
[1191265-33-4]
Product Name Alternative
RTA dh404
UNSPSC
12352211
Target
Apoptosis; Keap1-Nrf2; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cddo-dhtfea.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@]2([C@]13[H])[H])C)C(NCC(F)(F)F)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)[C@@]4([H])CC3=O)=O
Molecular Formula
C33H45F3N2O3
Molecular Weight
574.72
References & Citations
[1]Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31.|[2]Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44 (6) :570-8.|[3]Robles L, et al., Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas. 2016 May-Jun;45 (5) :720-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB

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MBS3844204-01CDDO-dhTFEA
A19751-100CDDO-dhTFEA 100mg
A19751-2CDDO-dhTFEA 2mg
A19751-10CDDO-dhTFEA 10mg
A19751-500CDDO-dhTFEA 500mg
A19751-5CDDO-dhTFEA 5mg
A19751-25CDDO-dhTFEA 25mg
A19751-50CDDO-dhTFEA 50mg
A19751-1CDDO-dhTFEA 1mg
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