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ADCY5 rabbit pAb

CAT: 0855-ES18456-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Description
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
UniProt
O95622
Swiss Prot
O95622
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human ADCY5 AA range: 471-521
Target
ADCY5
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein. Cell projection, cilium .
Gene ID (Human)
111

UniProtKB · O95622

Adenylate cyclase type 5

ADCY5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95622
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADCY5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
4.6.1.1
Processing
—
Secondary accessions
B7Z8A6, Q7RTV7, Q8NFM3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

cAMP biosynthesis

Cellular component

Cell membraneCell projectionCiliumMembrane

Disease

Disease variantIntellectual disability

PTM

GlycoproteinMethylationPhosphoprotein

Molecular function

Lyase

Domain

RepeatTransmembraneTransmembrane helix

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