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ADCYA rabbit pAb

CAT: 0855-ES18455-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES18455-01Size:50 µL
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Background
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
Description
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014],
UniProt
Q96PN6
Swiss Prot
Q96PN6
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human ADCYA AA range: 368-418
Target
ADCYA
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Nucleus . Cell projection, cilium . Cytoplasm . Mitochondrion . Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. .
Gene ID (Human)
55811

UniProtKB · Q96PN6

Adenylate cyclase type 10

ADCYA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96PN6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADCY10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
4.6.1.1
Processing
—
Secondary accessions
B4DZF0, F5GWS5, O95558, Q5R329, Q5R330, Q8WXV4, Q9NNX0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumManganeseMetal-bindingNucleotide-binding

Biological process

cAMP biosynthesis

Cellular component

Cell membraneCell projectionCytoplasmCytoskeletonMembraneMitochondrionNucleus

Molecular function

Lyase

Domain

Repeat

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