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GR 87389

CAT: 0804-HY-P3853Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3853Size:1 Each
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Description
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
CAS Number
141663-86-7
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr-87389.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(OC(C)(C)C)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O
Molecular Formula
C47H65N9O9
Molecular Weight
900.07
References & Citations
[1]Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79 (5) :985-96.|[2]Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277 (2) :700-5.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK2R

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