CDK2 degrader 1

CDK2 degrader 1

• CAS Number: 3036604-59-5
• UNSPSC Description: CDK2 degrader 1 (Compound 3) is an orally active cyclin-dependent kinase 2 (CDK2) degrader based on PROTAC technology. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers (Red: spiro[3.3]heptan-2- ylmethyl carbonochloridate; Blue: N,N-diisopropylethylamine; Black: linker)[1].
• Target Antigen: CDK; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk2-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: [H][C@](C1)(CC2)C[C@]2([H])[C@@H]1COC(NC3CN(C4=CC(F)=C(C5C(NC(CC5)=O)=O)C(F)=C4)C3)=O
• Molecular Weight: 447.47
• References & Citations: [1]Fasching B, et al. Compounds that mediate protein degradation and methods of use thereof[J]. US patent WO2023069700A1, 2022.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported