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Buformin (hydrochloride)

CAT: 0804-HY-B2099A-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B2099A-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1].
CAS Number
1190-53-0
Product Name Alternative
1-Butylbiguanide (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302, H315, H318, H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/buformin-hydrochloride.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
NC(NC(NCCCC)=N)=N.[H]Cl
Molecular Formula
C6H16ClN5
Molecular Weight
193.68
Precautions
H302, H315, H318, H335
References & Citations
[1]Amanda B Parris, et al. Buformin hydrochloride Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res|[2]Jing Li, et al. Buformin hydrochloride Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19 (6) :507-517.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Clin Sci. 2022 Feb 25;136 (4) :273-289.|Mol Metab. 2024 Jan:79:101860.|ACS Appl Nano Mater. 2023 Oct 26.

Chemical Information

Buformin Hydrochloride

Buformin Hydrochloride is the hydrochloride salt form of buformin, an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Buformin is not metabolized and is excreted in the urine. This agent has an elevated risk of causing lactic acidosis, and has been withdrawn from the market.

CAS Number1190-53-0
PubChem CID84976
IUPAC Name2-butyl-1-(diaminomethylidene)guanidine;hydrochloride
Molecular FormulaC6H16ClN5
Molecular Weight193.68
Topological Polar Surface Area103
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Heavy Atom Count12
Formal Charge0
Complexity156
SMILES
CCCCN=C(N)N=C(N)N.Cl
InChI
InChI=1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H
InChIKey
KKLWSPPIRBIEOV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Buformin Hydrochloride
CAS: 1190-53-0
CID: 84976
Formula: C6H16ClN5
MW: 193.68
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight193.68
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass193.1094232
Monoisotopic Mass193.1094232
Topological Polar Surface Area103 Ų
Heavy Atom Count12
Formal Charge0
Complexity156
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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