Buformin

CAT: 0804-HY-B2099Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B2099Size:1 Each
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Description
Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1].
CAS Number
[692-13-7]
Product Name Alternative
1-Butylbiguanide
UNSPSC
12352211
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/buformin.html
Solubility
10 mM in DMSO
Smiles
NC(NC(NCCCC)=N)=N
Molecular Formula
C6H15N5
Molecular Weight
157.22
References & Citations
[1]Amanda B Parris, et al. Buformin Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res|[2]Jing Li, et al. Buformin Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19 (6) :507-517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
ACS Appl Nano Mater. 2023 Oct 26.|Clin Sci. 2022 Feb 25;136 (4) :273-289.|Mol Metab. 2024 Jan:79:101860.

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