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Corynoline

CAT: 0804-HY-N0826-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0826-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
CAS Number
18797-79-0
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Cholinesterase (ChE) ; Keap1-Nrf2
Type
Natural Products
Related Pathways
Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/corynoline.html
Concentration
10mM
Purity
98.84
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
C[C@@]1(C(C=CC2=C3OCO2)=C3CN4C)[C@@]4([H])C(C=C(OCO5)C5=C6)=C6C[C@@H]1O
Molecular Formula
C21H21NO5
Molecular Weight
367.40
Precautions
H302+H312+H332
References & Citations
[1]Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25 (6) :817-9.|[2]Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS) -Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41 (5) :1640-1647.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE

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