Corydaline

CAT: 0804-HY-N0923-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0923-01Size:5 mg
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Description
Corydaline ((+) -Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM) . Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].
CAS Number
[518-69-4]
Product Name Alternative
(+) -Corydaline; Corydalin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE) ; Enterovirus; Opioid Receptor
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Corydaline.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@H](C1=CC=C2OC)[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC
Molecular Formula
C22H27NO4
Molecular Weight
369.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25 (15) :1418-22.|[2]Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19 (11) :1124-1133.|[3]Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10 (1) :13804.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE; μ Opioid Receptor/MOR

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