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Corynoxine B (Standard)

CAT: 0804-HY-N0901ARSize: 1 EachDry Ice: NoHazardous: No
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Description
Corynoxine B Standard is an analytical standard for Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is an alkaloid-type autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances the clearance of α-synuclein (α-syn) in Parkinson's disease mice[1][2][3][4].
CAS Number
17391-18-3
UNSPSC
12352005
Target
Reference Standards; α-synuclein
Type
Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/corynoxine-b-standard.html
Smiles
O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
References & Citations
[1]Yan D, et al. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019 Feb;124:336-348.|[2]Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10 (1) :144-54. doi: 10.4161/auto.26751. Epub 2013 Jan 1. Erratum in: Autophagy. 2015;11 (9) :1708.|[3]Zhu Q, et al. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13 (6) :2701-2714.|[4]Chen L, et al. Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease. Front Pharmacol. 2021 Apr 13;12:642900.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
α-synuclein Aggregation

Chemical Information

Corynoxine B

Corynoxine B is a member of indolizines. It has a role as a metabolite.

CAS Number17391-18-3
PubChem CID10091424
IUPAC Namemethyl (E)-2-[(3R,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Molecular FormulaC22H28N2O4
Molecular Weight384.5
XLogP2.3
Topological Polar Surface Area67.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity663
SMILES
CC[C@@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)C4=CC=CC=C4NC3=O
InChI
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22-/m1/s1
InChIKey
DAXYUDFNWXHGBE-XYEDMTIPSA-N
Chemical Structure
2D Structure
2D structure of Corynoxine B
CAS: 17391-18-3
CID: 10091424
Formula: C22H28N2O4
MW: 384.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.5
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass384.20490738
Monoisotopic Mass384.20490738
Topological Polar Surface Area67.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity663
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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