Corynoxine

• Description :

  Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H300

• Target :

  Autophagy

• Type :

  Natural Products

• Related Pathways :

  Autophagy

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Corynoxine.html

• Purity :

  99.89

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NC1=C2C=CC=C1)[C@@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3

• Molecular Formula :

  C22H28N2O4

• Molecular Weight :

  384.47

• Precautions :

  H300

• References & Citations :

  [1]Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9 (3) :380-7.|[2]Sakakibara I, et, al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5 (2) :83-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [6877-32-3]