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Corynoline

CAT: 0013-GTR19168435-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168435-01Size:5 mg
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Description
(+) -Corynoline is a natural alkaloid that acts as an acetylcholinesterase (AChE) inhibitor. It is utilized in neuroscience research to study cholinergic signaling and has been investigated in cellular and animal models for its potential neuropharmacological effects.
CAS Number
18797-79-0
Product Name Alternative
Corynoline, Cholinesterase (ChE), (+) -Corynoline, AChE, Inhibitor, Keap1-Nrf2, inhibit
Field of Research
Immunology & Inflammation, Neuroscience
Purity
98.17% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:1.00 mg/mL (2.72 mM) ; DMSO:13.00 mg/mL (35.38 mM) ; Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
Smiles
CN1Cc2c3OCOc3ccc2[C@@]2 (C) [C@@H] (O) Cc3cc4OCOc4cc3[C@@H]12
Molecular Formula
C21H21NO5
Molecular Weight
367.40
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Corynoline

Corynoline is a benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity. It has a role as a metabolite, an antineoplastic agent, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a hepatoprotective agent. It is a member of isoquinolines, a secondary alcohol, a benzophenanthridine alkaloid, an organic heterohexacyclic compound and a cyclic acetal. It is functionally related to a chelidonine.

CAS Number18797-79-0
PubChem CID177014
IUPAC Name(1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol
Molecular FormulaC21H21NO5
Molecular Weight367.4
XLogP2.7
Topological Polar Surface Area60.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Heavy Atom Count27
Formal Charge0
Complexity603
SMILES
C[C@]12[C@H](CC3=CC4=C(C=C3[C@H]1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O
InChI
InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1
InChIKey
IQUGPRHKZNCHGC-TYPHKJRUSA-N
Chemical Structure
2D Structure
2D structure of Corynoline
CAS: 18797-79-0
CID: 177014
Formula: C21H21NO5
MW: 367.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass367.14197277
Monoisotopic Mass367.14197277
Topological Polar Surface Area60.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity603
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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