CNS-11

• Description :

  CNS-11 is a blood-brain barrier permeable tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research[1][2].

• CAS Number :

  [445218-34-8]

• UNSPSC :

  12352005

• Target :

  Tau Protein; α-synuclein

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cns-11.html

• Purity :

  98.88

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1C2=C(C3=CC=C2)C(C4=CC=CC=C34)=NN1CC(NC(C(C)=CC(C)=C5)=C5C)=O

• Molecular Formula :

  C25H21N3O2

• Molecular Weight :

  395.45

• References & Citations :

  [1]Paul M Seidler, et al. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 Sep 16;13 (1) :5451. |[2]Murray KA, et al. Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 Feb 14;120 (7) :e2217835120.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported