Formycin triphosphate

• Description:

  Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF) -stimulated guanylate cyclase activity with an EC50 at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 at about 100 μM[1][2].

• UNSPSC:

  12352005

• Target:

  Guanylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/formycin-triphosphate.html

• Smiles:

  NC1=C2C(C([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=NN2)=NC=N1

• Molecular Formula:

  C10H16N5O13P3

• Molecular Weight:

  507.18

• References & Citations:

  [1]P V Attwood, et al. Interaction of formycin A-5'-triphosphate with pyruvate carboxylase. FEBS Lett. 1984 Sep 17;175 (1) :45-50.|[2]C H Chang, et al. Formycin triphosphate as a probe for the ATP binding site involved in the activation of guanylate cyclase. Eur J Pharmacol. 1992 Oct 1;227 (2) :229-31.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [16409-13-5]