Formycin A

• Description :

  Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2].

• Product Name Alternative :

  NSC 102811

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Antibiotic; HIV; Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/formycin-a.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NNC3=C2N=CN=C3N

• Molecular Formula :

  C10H13N5O4

• Molecular Weight :

  267.24

• Precautions :

  H302

• References & Citations :

  [1]Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88 (1) :354-63.|[2]Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86 (2) .

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1

• CAS Number :

  [6742-12-7]