AK-4

• Description:

  AK-4 is a glucose-lowering agent, acting function as a mitochondrial uncoupler[1].

• UNSPSC:

  12352005

• Target:

  Mitochondrial Metabolism

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ak-4.html

• Smiles:

  ClC(C=C(Cl)C=C1)=C1CN2C3=CC=CC=C3C(/C=C4SC(N(CC(O)=O)C\4=O)=O)=C2

• Molecular Formula:

  C21H14Cl2N2O4S

• Molecular Weight:

  461.32

• References & Citations:

  [1]Kousaxidis A, et al. Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler. Eur J Med Chem. 2025 Jan 5;281:117035.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported