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AK 295

CAT: 0804-HY-119378-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119378-01Size:1 mg
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Description
AK 295 (CX 295) is a selective calpain inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis[1][2][3].
CAS Number
[160399-35-9]
Product Name Alternative
CX 295
UNSPSC
12352005
Target
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ak-295.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(NC(C(C(NCCCN1CCOCC1)=O)=O)CC)=O)OCC2=CC=CC=C2
Molecular Formula
C26H40N4O6
Molecular Weight
504.62
References & Citations
[1]Colak A, et al. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur) . 2009 Jun;20 (3) :245-54.|[2]Bartus RT, et al. Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration. Stroke. 1994 Nov;25 (11) :2265-70.|[3]DeBiasi RL, et al. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol. 2001 Jan;75 (1) :351-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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